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KMID : 0043320100330010047
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.47 ~ p.54
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Synthesis and Microbiological Activity of Thiourea Derivatives of 4- Azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione
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Joanna Stefanska
Marta Struga
Szymon Rosolowski
Jerzy Kossakowski
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Abstract
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A series of thiourea derivatives of 4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione were synthesized. The compounds were investigated for antibacterial activity, including Gram-positive cocci, Gram-negative rods, and antifungal activity. Compounds 1b, 2b, 4b showed significant inhibition against Gram-positive cocci. Research was carried out over 10 standard strains and 20 hospital strains. Synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
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KEYWORD
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Synthesis, Thiourea derivatives, Antimicrobial activity, Cytotoxicity
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